Technically, yes. The Big Sur International Marathon is USATF certified and the official race website lists it as a Boston qualifier. Your finish time will be accepted by the BAA for qualifying purposes.
Practically? Almost nobody uses it for that.
Big Sur gains 2,188 feet over 26.2 miles with the most difficult terrain loaded into the second half. The course averages 84 feet of climbing per mile. There are 16 miles of direct wind exposure. The field size is small (roughly 4,500), and the race has a 6-hour cutoff (13:45 per mile pace). There is no pacing group, no flat straightaway longer than a few hundred meters, and no section of the course where you can settle into a predictable, sustainable rhythm for more than two miles without a hill, a curve, or a crosswind interrupting it.
For context: runners attempting a BQ typically choose courses specifically designed for fast times. California International Marathon (net downhill, Sacramento). Chicago (dead flat, massive field, pace groups). Grandma's Marathon (point-to-point, favorable wind profile). These courses exist to give you every possible advantage. Big Sur exists to give you an experience.
The numbers tell the story. A competitive runner whose flat-course PR is 3:30 (8:00/mile) might reasonably expect to run Big Sur in 3:36 to 3:48, based on historical performance data. That's a 6 to 18 minute penalty. For runners closer to their BQ standard, that margin is the difference between qualifying and not qualifying, and the cutoff buffer in recent years has required runners to be 5 to 7 minutes under the standard anyway.
Does anyone BQ at Big Sur? Sure. Fast, experienced runners who are well under their qualifying standard can absorb the time penalty and still hit their number. But they're BQ-ing in spite of the course, not because of it. If qualifying for Boston is your primary goal for this training cycle, Big Sur is not the race to choose.
And that's fine. That's actually the point.
Big Sur is not a race you run for a fast time. It's a race you run because you want to run through 800-year-old redwoods at dawn, climb a headland 560 feet above the Pacific into a wall of wind, cross the most photographed bridge in California while a pianist plays below you, and finish in Carmel-by-the-Sea. It's the closest thing running has to a pilgrimage. The time on the clock at the end is genuinely secondary to the experience of covering those 26.2 miles.
If you want Boston, go to Sacramento. If you want Big Sur, come to Big Sur. Just don't try to do both on the same day.